Visualizing mitochondrial dynamics at the nanoscale.

Till StephanPeter IlgenStefan Jakobs

Published in: Light, science & applications (2024)

The study of mitochondria is a formidable challenge for super-resolution microscopy due to their dynamic nature and complex membrane architecture. In this issue, Ren et al. introduce HBmito Crimson, a fluorogenic and photostable mitochondrial probe for STED microscopy and investigate how mitochondrial dynamics influence the spatial organization of mitochondrial DNA.

Keyphrases

mitochondrial dna
oxidative stress
copy number
single molecule
high resolution
high speed
living cells
high throughput
optical coherence tomography
atomic force microscopy
cell death
quantum dots
gene expression
label free