Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality.
Jared A GreenbergCara L HruschMohammad R JafferyMichael Z DavidRobert S DaumJesse B HallJohn P KressAnne I SperlingPhilip A VerhoefPublished in: Critical care (London, England) (2018)
The association of both increased Th17 responses and increased neutrophil counts relative to lymphocyte counts with mortality suggests that an overwhelming inflammatory response is detrimental. However, the differential responses of patients according to immune state suggest that immune status is an important clinical indicator that should be accounted for in the management of septic patients, as well as in the development of novel immunomodulatory therapies.
Keyphrases
- end stage renal disease
- staphylococcus aureus
- ejection fraction
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- cardiovascular events
- peripheral blood
- type diabetes
- patient reported outcomes
- risk factors
- dendritic cells
- pseudomonas aeruginosa
- regulatory t cells
- cystic fibrosis
- mesenchymal stem cells
- multidrug resistant