How to open a proton pore-more than S4?

Marcel P Goldschen-OhmBaron Chanda

Published in: Nature structural & molecular biology (2015)

Pioneering studies in voltage-gated potassium channels have described movement of the voltage-sensing domain (VSD) S4 helix across the membrane electric field in molecular detail, but much less is known regarding opening of the intrinsic proton pore within VSDs of voltage-dependent proton channels. By systematically probing local kinematics, a new study reveals that movements in helix S1 correlate with pore opening and are distinct from voltage-sensing movements of the charged S4 segment.

Keyphrases

dna binding
single molecule
electron transfer
molecular dynamics simulations
case control
transcription factor