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Navigating the HER2-Low Paradigm in Breast Oncology: New Standards, Future Horizons.

Paolo TarantinoCurigliano GiuseppeSara M Tolaney
Published in: Cancer discovery (2022)
The confirmation of the HER2-low paradigm is expected to have a major impact in breast oncology. About half of all breast cancers harbor HER2-low expression, which can be targeted with the anti-HER2 antibody-drug conjugate trastuzumab deruxtecan (T-DXd), leading to a relevant survival benefit in the metastatic setting. Given this observation, treatment algorithms for both hormone receptor-positive and triple-negative breast cancer are expected to significantly evolve in the next future. Several challenges, however, remain in the interpretation of HER2-low expression related to its biological role, its pathologic diagnosis, and the definition itself of HER2-low. In this article, we recapitulate the current knowledge on HER2-low breast cancer, discussing whether it should be considered a distinct subtype, how it should be implemented in the clinic, and how its definition may evolve in the coming years with the evolution of our clinical and translational knowledge.
Keyphrases
  • squamous cell carcinoma
  • machine learning
  • primary care
  • cancer therapy
  • deep learning
  • neoadjuvant chemotherapy
  • long non coding rna
  • combination therapy
  • tyrosine kinase
  • binding protein