Association of MAPT H1 subhaplotypes with neuropathology of lewy body disease.
Michael G HeckmanKoji KasanukiRebecca R BrennanCatherine LabbéEmily R VargasAlexandra I SotoMelissa E MurrayShunsuke KogaDennis W DicksonOwen A RossPublished in: Movement disorders : official journal of the Movement Disorder Society (2019)
A rare microtubule-associated protein tau H1 subhaplotype (H1j) may be associated with more severe putaminal dopaminergic degeneration in Lewy body disease cases. Microtubule-associated protein tau H1j has been associated previously with an increased risk of PD, and therefore our exploratory findings provide insight into the mechanism by which H1j modulates PD risk. © 2019 International Parkinson and Movement Disorder Society.