Mechanism and restoration strategy of lysosomal abnormalities induced by urinary protein overload in proximal tubule epithelial cells.

Xiaoyu LiTing ZouShujun WangHongluan WuMan WuZejian LiuHuafeng Liu

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)

These results indicate that abnormal TFEB expression is a key mechanism of lysosomal dyshomeostasis caused by protein overload in PTECs. TFEB is thus a potential therapeutic target for the treatment of urinary protein-related kidney disease.

Keyphrases

binding protein
protein protein
amino acid
long non coding rna
combination therapy