High-resolution targeted bisulfite sequencing reveals blood cell type-specific DNA methylation patterns in IL13 and ORMDL3.

Cilla SöderhällLovisa E ReiniusPertteli SalmenperäMassimiliano GentileNathalie AcevedoJon R KonradsenBjörn NordlundGunilla HedlinAnnika ScheyniusSamuel MyllykangasJuha Kere

Published in: Clinical epigenetics (2021)

We conclude that high-resolution methylation studies can yield clinically important information at selected specific loci missed by array-based methods, with potential implications for future studies of methylation-disease associations.

Keyphrases

high resolution
dna methylation
genome wide
gene expression
case control
mass spectrometry
high throughput
tandem mass spectrometry
single cell
current status
health information
copy number
social media
high speed
drug delivery
human health