EP 1 receptor antagonism mitigates early and late stage renal fibrosis.

Jean-Claude Kresse Henricus A M Mutsaers Michael Schou JensenStine Julie TingskovMia Gebauer Madsen Lene N Nejsum Helle A Praetorius Rikke Nørregaard

Published in: Acta physiologica (Oxford, England) (2022)

receptor as a promising target for preventing both the onset and late stage of renal fibrosis. Moreover, we provide strong evidence that the effect of SC-19220 may translate to clinical care since its effects were observed in UUO mice, cells and human kidney slices.

Keyphrases

induced apoptosis
endothelial cells
healthcare
palliative care
cell cycle arrest
quality improvement
high fat diet induced
induced pluripotent stem cells
liver fibrosis
type diabetes
pain management
cell death
oxidative stress
metabolic syndrome
adipose tissue
skeletal muscle
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