Orlistat attenuates obesity-induced decline in steroidogenesis and spermatogenesis by up-regulating steroidogenic genes.
Joseph Bagi SuleimanVictor Udo NnaZaidatul Akmal OthmanZaida ZakariaAinul Bahiyah Abu BakarMahaneem MohamedPublished in: Andrology (2020)
Orlistat attenuated impaired spermatogenesis and steroidogenesis decline by up-regulating steroidogenic genes. This may not be unconnected to its significant effect in lowering serum leptin levels, since the hormone is known to dampen fertility potential. Therefore, orlistat may improve fertility potential in overweight/obese men.
Keyphrases
- weight loss
- metabolic syndrome
- genome wide
- type diabetes
- weight gain
- bariatric surgery
- insulin resistance
- bioinformatics analysis
- genome wide identification
- human health
- diabetic rats
- physical activity
- drug induced
- dna methylation
- childhood cancer
- obese patients
- risk assessment
- middle aged
- transcription factor
- climate change
- skeletal muscle
- endothelial cells