Inter-crystal scattering recovery of light-sharing PET detectors using convolutional neural networks.

Inter-crystal scattering (ICS) is a type of Compton scattering of photons from one crystal to adjacent crystals and causes inaccurate assignment of the annihilation photon interaction position in positron emission tomography (PET). Because ICS frequently occurs in highly light-shared PET detectors, its recovery is crucial for the spatial resolution improvement. In this study, we propose two different convolutional neural networks (CNNs) for ICS recovery, exploiting the good pattern recognition ability of CNN techniques. Using the signal distribution of a photosensor array as input, one network estimates the energy deposition in each crystal (ICS-eNet) and another network chooses the first-interacted crystal (ICS-cNet). We performed GATE Monte Carlo simulations with optical photon tracking to test PET detectors comprising different crystal arrays (8 × 8 to 21 × 21) with lengths of 20 mm and the same photosensor array (3 mm 8 × 8 array) covering an area of 25.8 × 25.8 mm2. For each detector design, we trained ICS-eNet and ICS-cNet and evaluated their respective performance. ICS-eNet accurately identified whether the events were ICS (accuracy > 90%) and selected interacted crystals (accuracy > 60%) with appropriate energy estimation performance (R2 > 0.7) in the 8 × 8, 12 × 12, and 16 × 16 arrays. ICS-cNet also exhibited satisfactory performance, which was less dependent on the crystal-to-sensor ratio, with an accuracy enhancement that exceeds 10% in selecting the first-interacted crystal and a reduction in error distances compared when no recovery was applied. Both ICS-eNet and ICS-cNet exhibited consistent performances under various optical property settings of the crystals. For spatial resolution measurements in PET rings, both networks achieved significant enhancements particularly for highly pixelated arrays. We also discuss approaches for training the networks in an actual experimental setup. This proof-of-concept study demonstrated the feasibility of CNNs for ICS recovery in various light-sharing designs to efficiently improve the spatial resolution of PET in various applications.