Evaluation of a photodynamic therapy agent using a canine prostate cancer model.
Dong LuoXinning WangGopalakrishnan RamamurthyEthan WalkerLifang ZhangAditi ShirkeNaraen G NaiduClemens BurdaReena ShakyaEric T HostnikMathew JosephLee PonskyVladimir PonomarevThomas J RosolMichael F TweedleJames P BasilionPublished in: The Prostate (2023)
We have successfully established a PSMA-expressing canine orthotopic prostate tumor model and used the model to evaluate the PSMA-targeted nano agents (AuNPs-Pc158) in the application of FL imaging and PDT. It was demonstrated that the nano agents allowed visualization of the cancer cells and enabled their destruction when they were irradiated with a specific wavelength of light.