Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis.
Kevin KleffmanGrace LevinsonIndigo V L RoseLili M BlumenbergSorin A A ShadaloeyAvantika DhabariaEitan WongFrancisco Galán-EchevarríaAlcida KarzDiana ArgibayRichard Von ItterAlfredo FloristánGillian BaptisteNicole M EskowJames A TranosJenny ChenEleazar C Vega Y Saenz de MieraMelissa CallRobert RogersGeorge JourYoussef Zaim WadghiriIman OsmanYue-Ming LiPaul MathewsRonald B DeMattosBeatrix UeberheideKelly V RugglesShane A LiddelowRobert J SchneiderEva HernandoPublished in: Cancer discovery (2022)
Our results reveal a novel mechanistic connection between brain metastasis and Alzheimer's disease, two previously unrelated pathologies; establish Aβ as a promising therapeutic target for brain metastasis; and demonstrate suppression of neuroinflammation as a critical feature of metastatic adaptation to the brain parenchyma. This article is highlighted in the In This Issue feature, p. 1171.