Evolution of lung adenocarcinoma from preneoplasia to invasive adenocarcinoma.

Jianfei ZhuWenchen WangYanlu XiongShuonan XuJiankuan ChenMiaomiao WenYabo ZhaoJie LeiXiaofeng Guo

Published in: Cancer medicine (2022)

The accumulation of EGFR driver gene mutation frequencies mediates the progression of LUAD from AIS to MIA. When the tumour progresses to stage IA invasive adenocarcinoma, multivariate analysis based on driver gene status can be used as a pivotal prognostic factor.

Keyphrases

prognostic factors
squamous cell carcinoma
small cell lung cancer
locally advanced
epidermal growth factor receptor
tyrosine kinase
genome wide
copy number
data analysis
gene expression
dna methylation