Minocycline attenuates cholinergic dysfunction and neuro-inflammation-mediated cognitive impairment in scopolamine-induced Alzheimer's rat model.

Sabiheh AmirahmadiFaezeh Dabouri FarimaniMahsan AkbarianFarshad MirzaviMohammad Hossein Eshaghi GhalibafArezoo RajabianMahmoud Hosseini

Published in: Inflammopharmacology (2022)

Taken together, the data indicate that treatment with minocycline improved memory dysfunction mediated possibly through restoring AChE and ChRM1 levels, oxidant/antioxidant balance, as well as inhibiting inflammatory responses.

Keyphrases

oxidative stress
cognitive impairment
diabetic rats
anti inflammatory
high glucose
signaling pathway
working memory
electronic health record
cognitive decline
big data
data analysis