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Enterically delivered insulin tregopil exhibits rapid absorption characteristics and a pharmacodynamic effect similar to human insulin in conscious dogs.

Justin M GregoryMargaret LautzLindsey M MoorePhillip E WilliamsPraveen ReddyAlan D Cherrington
Published in: Diabetes, obesity & metabolism (2018)
Enterically delivered tregopil is rapidly absorbed and restores a portal-to-peripheral vascular distribution. These characteristics should improve postprandial hyperglycaemia in types 1 and 2 diabetes.
Keyphrases
  • type diabetes
  • glycemic control
  • endothelial cells
  • blood glucose
  • cardiovascular disease
  • induced pluripotent stem cells
  • insulin resistance
  • blood pressure
  • weight loss
  • adipose tissue