IFN-γ regulates a complex pro-survival signal network in CLL.

Yixiang ChenXiaoya ShaoHaiping YangLeiying RenYing CuiWenlu ZhangSalvador MacipXueqiong Meng

Published in: European journal of haematology (2022)

Our data demonstrates that IFN-γ regulates a complex pro-survival signal network in CLL through JAK1/2-STAT3, which provides a rational explanation for IFN-γ promoting CLL cells survival and drug resistance. This article is protected by copyright. All rights reserved.

Keyphrases

dendritic cells
immune response
chronic lymphocytic leukemia
free survival
induced apoptosis
anti inflammatory
electronic health record
cell cycle arrest
big data
machine learning
signaling pathway
cell death
data analysis