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Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis.

Gail D Lewis PhillipsMerry C NishimuraJennifer Arca LacapSamir KharbandaElaine MaiJanet TienKimberly MaleskySimon P WilliamsJan MarikHeidi S Phillips
Published in: Breast cancer research and treatment (2017)
In models of HER2-positive breast cancer brain metastasis, trastuzumab efficacy does not appear to be limited by access to intracranial tumors. Anti-tumor activity improved with the addition of a brain-penetrant PI3K/mTOR inhibitor, suggesting that combining targeted therapies is a more effective strategy for treating HER2-positive breast cancer brain metastases. Survival was also extended in mice with Fo5 brain lesions treated with T-DM1.
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