Neuroprotective Effects of Berberine Hydrochloride on Methamphetamine-induced Cognitive Dysfunction: Immunohistochemical and Behavioral Studies in Rats.
Leila RezaeianMehdi KhaksariRaheleh RafaieeHamid Kalalian MoghaddamPublished in: Basic and clinical neuroscience (2022)
Methamphetamine (MA) is known as a strong addictive stimulant with high addiction and no approved pharmaco-therapy, as well as confirmed medication, is available to treat MA abuse. The study on the long-term effect of MA exposure on cognitive function during an object recognition memory test showed cognitive dysfunction after MA exposure. Berberine can reduce induced amnesia, which can be due to the increased peripheral and central cholinergic neuronal system functions, in addition, the most important mechanism in the protective effect of berberine against amnesia is the inhabitation of inflammation; however, the berberine impact on cells should be more investigated.
Keyphrases
- diabetic rats
- high glucose
- oxidative stress
- working memory
- induced apoptosis
- attention deficit hyperactivity disorder
- drug induced
- healthcare
- stem cells
- emergency department
- high resolution
- cell proliferation
- mesenchymal stem cells
- signaling pathway
- brain injury
- cerebral ischemia
- adverse drug
- atomic force microscopy
- drug administration
- replacement therapy