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Time to reconsider the role of ribavirin in Lassa fever.

Alex Paddy SalamHung-Yuan ChengTansy EdwardsPiero L OlliaroJonathan A C SternePeter W Horby
Published in: PLoS neglected tropical diseases (2021)
Ribavirin is the only available Lassa fever treatment. The rationale for using ribavirin is based on one clinical study conducted in the early 1980s. However, reanalysis of previous unpublished data reveals that ribavirin may actually be harmful in some Lassa fever patients. An urgent reevaluation of ribavirin is therefore needed.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • chronic kidney disease
  • newly diagnosed
  • peritoneal dialysis
  • electronic health record
  • patient reported outcomes