Cortisol response in children with cancer and fever during chemotherapy: A prospective, observational study using random serum cortisol levels.
Ann BoekstegersHeinrich SchmidtMathias KurzayTanja ValléeEva JungIlja DubinskiRebecca MaxwellIrene SchmidPublished in: Cancer medicine (2023)
The incidence of an impaired HPA axis in pediatric cancer patients might be underestimated since 69% of the children in our study had a LCR during fever. Intake of dexamethasone, posaconazole and a time period of ≤7 days from the last glucocorticoid intake were additional risk factors for an LCR. However, we could not confirm that patients with a LCR fared worse than patients with a high cortisol response (HCR). Therefore, a different cortisol threshold may be necessary for defining an impaired HPA axis in febrile oncologic patients without concomitant symptoms of AI.
Keyphrases
- end stage renal disease
- young adults
- newly diagnosed
- ejection fraction
- chronic kidney disease
- papillary thyroid
- prognostic factors
- peritoneal dialysis
- risk factors
- low dose
- artificial intelligence
- prostate cancer
- rectal cancer
- squamous cell carcinoma
- patient reported outcomes
- machine learning
- locally advanced
- radiation therapy
- robot assisted
- squamous cell
- chemotherapy induced
- sleep quality
- neural network