Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase.

Laura Boucai Federico Salas-LuciaGnana P KrishnamoorthyEric J Sherman Charles M Rudin Alexander E Drilon Antonio Carlos Bianco James A Fagin

Published in: JCO precision oncology (2022)

An off-target effect of selpercatinib on D2-mediated T3 production leads to clinical hypothyroidism, primarily in levothyroxine-treated athyreotic patients. Liothyronine supplementation was needed to achieve normal T3 levels and restore clinical euthyroidism.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
high glucose
replacement therapy
diabetic rats
oxidative stress
endothelial cells
drug induced