Clinical Features and Risk of Relapse in Children and Adults with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
Álvaro Cobo-CalvoAnne RuizFabien RollotGeorgina ArrambideRomain DeschampsElisabeth MaillartCaroline PapeixBertrand AudoinAnne Fabienne LépineHélène MaureyHelene ZephirDamien BiottiJonathan CironFrancoise Durand-DubiefNicolas CollonguesXavier AyrignacPierre LabaugePierre MeyerEric ThouvenotBertrand BourreAlexis MontcuquetMikael CohenPhilippe HorelloMar TintoréJerome De SezeSandra VukusicKumaran DeivaRomain Marigniernull nullPublished in: Annals of neurology (2020)
MOGAD patients differ in the clinical presentation at onset, showing an age-related shift in the clinical features across age groups. Compared to children, adults have a higher risk of relapse and worse functional recovery. Finally, children with monophasic disease become MOG-Ab negative earlier than relapsing children, but this is not true in adults. Considering these differences, management and treatment guidelines should be considered independently in children and adults. ANN NEUROL 2021;89:30-41.