An anionic water-soluble [2]biphenyl-extended-pillar[6]arenes modified with eight ammonium salt ions (AWBpP6) was successfully synthesized to establish a drug-drug conjugate supramolecular nanoprodrug (SNP) with a high drug-loading capacity. This SNP can generate a synergistic triple therapeutic effect of photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy (CT; i.e., PDT-PTT-CT) with excellent biocompatibility.
Keyphrases
- water soluble
- photodynamic therapy
- combination therapy
- computed tomography
- genome wide
- image quality
- contrast enhanced
- fluorescence imaging
- adverse drug
- magnetic resonance imaging
- drug induced
- positron emission tomography
- high density
- emergency department
- magnetic resonance
- locally advanced
- dna methylation
- squamous cell carcinoma
- radiation therapy
- ionic liquid
- energy transfer
- aqueous solution