Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: New therapeutic targets.

Alvaro Santos-LasoLaura Izquierdo-SanchezPedro M RodriguesBing Q HuangMikel AzkargortaAinhoa LapitzPatricia Munoz-GarridoAnder ArbelaizFrancisco J Caballero-CaminoMaite G Fernández-BarrenaRaul Jimenez-AgüeroJosepmaria ArgemiTomas AragonFelix ElortzaMarco MarzioniJoost P H DrenthNicholas F LaRussoLuis BujandaMaria J PerugorriaJesus Maria Banales

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

Restoration of proteostasis in cystic cholangiocytes with 4-PBA halts hepatic cystogenesis, emerging as a novel therapeutic strategy.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
oxidative stress