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Exploring Novel Sensor Design Ideas through Concentration-Induced Conformational Changes in PEG Single Chains.

Miao YuChong JiangBing LaiKai Zhang
Published in: Sensors (Basel, Switzerland) (2024)
Polyethylene glycol (PEG) is an artificial polymer with good biocompatibility and a low cost, which has a wide range of applications. In this study, the dynamic response of PEG single chains to different ion concentrations was investigated from a microscopic point of view based on single-molecule force spectroscopy, revealing unique interactions that go beyond the traditional sensor-design paradigm. Under low concentrations of potassium chloride, PEG single chains exhibit a gradual reduction in rigidity, while, conversely, high concentrations induce a progressive increase in rigidity. This dichotomy serves as the cornerstone for a profound understanding of PEG conformational dynamics under diverse ion environments. Capitalizing on the remarkable sensitivity of PEG single chains to ion concentration shifts, we introduce innovative sensor-design ideas. Rooted in the adaptive nature of PEG single chains, these sensor designs extend beyond the traditional applications, promising advancements in environmental monitoring, healthcare, and materials science.
Keyphrases
  • single molecule
  • drug delivery
  • healthcare
  • low cost
  • public health
  • molecular dynamics simulations
  • high resolution
  • intellectual disability
  • high glucose
  • stress induced