No association between oral contraceptive exposure and subsequent MS: A population-based nested case-control study in primary care.
Qiqi ZhangAlastair J NoyceJohn RobsonGavin GiovannoniCharles R MarshallChu-Yueh GuoPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2024)
A total of 4455 females were included: 891 cases and 3564 controls. No association was seen between oral contraceptive exposure and subsequent MS, or between any contraceptive, combined oral contraceptive pill (COCP) or progesterone-only pill (POP) use 0-2, 2-5 or >5 years prior to MS. Conclusions: In the largest population-based study to date, we find no evidence of an association between oral contraceptive exposure and subsequent MS diagnosis.