Overexpression of CD200 is a Stem Cell-Specific Mechanism of Immune Evasion in AML.

Shelley M HerbrichNatalia BaranTianyu CaiConnie WengMarisa J L AitkenSean M PostJared HendersonChunhua ShiGuillame Richard-CarpentierGuy SauvageauKeith BaggerlyGheath Al-AtrashR Eric DavisNaval DaverDongxing ZhaMarina Konopleva

Published in: Journal for immunotherapy of cancer (2022)

Overexpression of CD200 is a stem cell-specific marker that contributes to immunosuppression in AML by impairing effector cell metabolism and function. CD200 antibody therapy is capable of simultaneously reducing CD200-mediated suppression while also engaging macrophage activity. This study lays the groundwork for CD200-targeted therapeutic strategies to eliminate LSCs and prevent AML relapse.

Keyphrases

stem cells
acute myeloid leukemia
nk cells
cell proliferation
adipose tissue
allogeneic hematopoietic stem cell transplantation
single cell
mesenchymal stem cells
regulatory t cells
type iii