High prevalence of hepatitis A in indigenous population in north Brazil.
Vanessa Salete de PaulaFlavio Augusto Pádua MilagresGuilherme de Macêdo OliveiraJuliana Custódio MiguelHelena Medina CruzLeticia de Paula ScalioniVanessa Alves MarquesMonica de Avelar Figueiredo Mafra MagalhãesAnselmo Rocha RomãoRenata GracieLivia Melo VillarPublished in: BMC research notes (2020)
A total of 872 serum samples were obtained from 491 indigenous and 381 non indigenous individuals aging 0 to 90 years. Samples were tested for total and IgM anti-HAV and positive IgM samples were tested for HAV RNA. The overall prevalence of total anti-HAV was 87%, increased according age showing 100% of prevalence in those aging more than 30 years (p < 0.0001) and it was similar among indigenous and urban population. Total anti-HAV prevalence varied between tribes (p < 0.0001) and urban sites (p = 0.0014) and spatial distribution showed high prevalence in homes that received up to 100 dollars. IgM anti-HAV prevalence was 1.7% with predominance in males, those aging more than 41 years. No HAV RNA was detected. In conclusion, high overall anti-HAV prevalence was found in indigenous communities in North Brazil demonstrating the importance of universal vaccination in this group.
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