Analysis of plasma HER2 copy number in cell-free DNA of breast cancer patients: a comparison with HER2 extracellular domain protein level in serum.

Shi QuiTakashi TakeshitaAiko SuetaMai TomiguchiLisa Goto-YamaguchiKaori HidakaIkuko SuzuYutaka YamamotoHirotaka Iwase

Published in: Breast cancer (Tokyo, Japan) (2021)

Compared to HER2-ECD levels, the clinical usefulness of HER2-CN ratio was somewhat inferior. Improved measurement methods and further examination of the association with long-term prognosis and the response to anti-HER2 treatment analyzed by HER2-CN and HER2-ECD assay are required.

Keyphrases

copy number
mitochondrial dna
lymph node metastasis
genome wide
dna methylation
high throughput
protein protein
amino acid
binding protein
combination therapy
small molecule