Next generation sequencing of high-grade adult-type diffuse glioma in the Netherlands: interlaboratory variation in the primary diagnostic and recurrent setting.
Mark P van OpijnenMarike L D BroekmanEdwin CuppenHendrikus J DubbinkArja Ter ElstRonald van EijkAngelika MühlebnerCasper JansenRobert van der GeizeErnst-Jan M SpeelPatricia J T A GroenenFilip Y F de VosPieter WesselingWendy W J de LengSybren L N MaasPublished in: Journal of neuro-oncology (2024)
Current notable interlaboratory variations as illustrated in this study should be reduced in order to refine diagnostics and improve precision oncology. In-house developed tests, standardized panels and routine application of broad gene panels all have their own advantages and disadvantages. Future research would be of interest to study the clinical impact of variation in diagnostic approaches.