Very low prevalence of Mansonella perstans-specific cell-free DNA in serum samples of Ghanaian HIV patients.
Kirsten Alexandra EberhardtLuzia VeletzkyFelix WeinreichRichard Odame PhillipsFred Stephen SarfoTorsten FeldtAlbert DomprehShadrack Osei AsibeyRichard BoatengHagen FrickmannPublished in: European journal of microbiology & immunology (2023)
Future epidemiological studies on hypothetical associations between mansonellosis and HIV infections should focus more specifically on high-endemicity settings for both Mansonella spp.-infections and HIV-infections, include higher case numbers and be based on real-time PCR from whole blood rather than from serum, in which only circulating parasite DNA but no more cell-bound parasite DNA can be detected. However, the study did not show associations of HIV infections in Ghanaian individuals with Mansonella worm loads high enough to detect cell-free Mansonella DNA in serum by PCR.
Keyphrases
- cell free
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- circulating tumor
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- real time pcr
- single molecule
- south africa
- ejection fraction
- risk factors
- stem cells
- prognostic factors
- circulating tumor cells
- current status
- cell therapy
- plasmodium falciparum