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Synthesis of One-Component Nanostructured Polyion Complexes via Polymerization-Induced Electrostatic Self-Assembly.

Meng CaiYi DingLei WangLeilei HuangXinhua LuYuanli Cai
Published in: ACS macro letters (2018)
Nanostructured polyion complexes (PICs) are expected to serve as novel platforms to stabilize and deliver drugs, proteins, and nucleic acids. Yet, traditional self-assembly suffers from lack of scale-up and reproducibility. Particularly for one-component PICs, only spheres are available to date. Here, we report an efficient and scalable strategy to prepare one-component low-dimensional PICs. It involves visible-light-mediated RAFT iterative polymerization of opposite-charge monomers at 25% w/w solids in water at 25 °C. Sphere-film-vesicle transition and charge-/medium-tunable shape selectivity are reported. One-component PIC nanowire, ultrathin film, vesicle, tube, and surface-charged vesicle are easily prepared, and vesicle-polymerization is fulfilled, using this new strategy. This strategy provides a general platform to prepare one-component low-dimensional PICs with tailorable morphologies and high reproducibility on commercially viable scale under eco-friendly conditions.
Keyphrases
  • visible light
  • room temperature
  • magnetic resonance imaging
  • computed tomography
  • magnetic resonance
  • endothelial cells
  • electron transfer