The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis.
Akira SaitoMasafumi HoriePatrick MickeTakahide NagasePublished in: International journal of molecular sciences (2018)
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth factor (TGF)-β signaling plays a central role in tissue fibrosis and tumorigenesis. TGF-β-mediated pathological changes that occur in IPF lung tissue may promote the process of field cancerization and provide the microenvironment favorable to cancer initiation and progression. This review summarizes the current knowledge related to IPF pathogenesis and explores the molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF, with an emphasis on the multifaceted effects of TGF-β signaling.
Keyphrases
- idiopathic pulmonary fibrosis
- transforming growth factor
- epithelial mesenchymal transition
- interstitial lung disease
- end stage renal disease
- decision making
- healthcare
- ejection fraction
- newly diagnosed
- multiple sclerosis
- stem cells
- peritoneal dialysis
- papillary thyroid
- prognostic factors
- smoking cessation
- replacement therapy
- patient reported
- systemic sclerosis
- childhood cancer