Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1α (Hypoxic-Inducible Factor-1 Alpha).
Dongling LuoWenxin LiChangming XieLi YinXiaoyan SuJie ChenHui HuangPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
Capsaicin facilitates deacetylation and degradation of Hif1α by upregulating SIRT6, which inhibits osteogenic transdifferentiation and protects against arterial calcification. These data highlight a promising therapeutic target for the management of arterial calcification.