Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes.

Masaki NagayaKoki HasegawaMasahito WatanabeKazuaki NakanoKazutoshi OkamotoTakeshi YamadaAyuko UchikuraKenji OsafuneHarumasa YokotaTaiji NagaokaHitomi MatsunariKazuhiro UmeyamaEiji KobayashiHiromitsu NakauchiHiroshi Nagashima

Published in: BMJ open diabetes research & care (2021)

Pdx1-Hes1 Tg pigs were an attractive model for the analysis of pancreatic development and testing of novel treatment strategies for diabetes.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
early onset