Kinetics of the Cell Cycle Arrest Biomarkers (TIMP2 and IGFBP7) for the Diagnosis of Acute Kidney Injury in Critically Ill COVID-19 Patients.

Massimiliano Greco Silvia De RosaFabian BoehmSofia SpanoRomina AcetoAntonio VozaFrancesco Reggiani Marta CalatroniGianluca CastellaniElena CostantiniGianluca VillaMaurizio Cecconi

Published in: Diagnostics (Basel, Switzerland) (2023)

Urinary biomarkers [TIMP-2]*[IGFBP-7] were generally increased in this population with a high prevalence of AKI, and were higher in patients with severe AKI measured at 12 h from ICU admission. Further studies are needed to evaluate the best timing of these biomarkers in this population.

Keyphrases

cell cycle arrest
acute kidney injury
cell death
emergency department
intensive care unit
pi k akt
early onset
signaling pathway
cell proliferation
extracorporeal membrane oxygenation