Lignans from Lepidium meyenii and Their Anti-Inflammatory Activities.
Yi-Yan ZouDai-Wei WangYong-Ming YanYong-Xian ChengPublished in: Chemistry & biodiversity (2021)
Meyeniines A-C (1-3), three new lignans, two known neolignans (4-5), and three known lignans (6-8) were isolated from the rhizomes of Lepidium meyenii. Their structures were identified by comprehensive spectroscopic analyses and computational methods. Compound 1 represents a unique lignan featuring an aromatic ring migration. Compounds 2 and 4-6 were analyzed by chiral HPLC column as enantiomers. Biological evaluation revealed that compound 8 could inhibit IL-6 production in lipopolysaccharide (LPS) induced RAW264.7 cells in a dose-dependent manner.
Keyphrases
- lps induced
- inflammatory response
- anti inflammatory
- induced apoptosis
- ms ms
- capillary electrophoresis
- cell cycle arrest
- solid phase extraction
- molecular docking
- simultaneous determination
- mass spectrometry
- liquid chromatography
- high resolution
- single cell
- toll like receptor
- amino acid
- ionic liquid
- cell proliferation
- signaling pathway