Genomic imprinting does not reduce the dosage of UBE3A in neurons.

Paul R HillmanSarah G B ChristianRyan DoanNoah D CohenKranti KongantiKory DouglasXu WangPaul B SamollowScott V Dindot

Published in: Epigenetics & chromatin (2017)

Based on our findings, we propose that imprinting of UBE3A does not function to reduce the dosage of UBE3A in neurons but rather to regulate some other, as yet unknown, aspect of gene expression or protein function.

Keyphrases

gene expression
spinal cord
dna methylation
copy number
spinal cord injury
protein protein