Role of SAA1 in endometrial extracellular matrix remodeling in polycystic ovary syndrome: implication for pregnancy loss.

Qinling ZhuYuan WangLizhen XuMengjia ShiYiwen MengCongwen ShaoYao LuYaqiong HeJiaan HuangXinyu LiBoyu LiYijing LongYing DingJia QiWangsheng WangYanzhi DuYun Sun

Published in: The Journal of clinical endocrinology and metabolism (2024)

The locally elevated levels of SAA1 in endometrium contribute to ECM over-deposition by inducing collagen I synthesis in PCOS patients, which may hamper embryo implantation and increase the risk of pregnancy loss. These observations highlight the crucial role of heightened SAA1 in orchestrating endometrial dysfunction and shed light on potential therapeutic avenues for improving reproductive outcomes in PCOS patients.

Keyphrases

polycystic ovary syndrome
extracellular matrix
end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
insulin resistance
prognostic factors
pregnant women
oxidative stress
patient reported outcomes
adipose tissue
endometrial cancer
weight loss