Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration.

Dibyadeep DattaIsabella PeroneDenethi WijegunawardanaFeng LiangYury M MorozovJon ArellanoAlvaro DuqueZhongcong XieChristopher H van DyckAmy F T Arnsten

Published in: bioRxiv : the preprint server for biology (2023)

These data help to explain why pT217-tau predicts degeneration in AD and how it gains access to CSF and plasma to serve as a fluid biomarker.

Keyphrases

prefrontal cortex
early stage
cerebrospinal fluid
high resolution
electronic health record
big data
atomic force microscopy
sentinel lymph node
machine learning
data analysis
high frequency
neoadjuvant chemotherapy