Diabetes accelerates Alzheimer's disease progression in the first year post mild cognitive impairment diagnosis.
Xiahao DingLi YinLin ZhangYang ZhangTianming ZhaWen ZhangBo Guinull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Diabetes mellitus (DM) accelerates mild cognitive impairment (MCI)-to-Alzheimer's disease (AD) progression within the first year after MCI diagnosis. DM leads to sharper cognitive decline within 12 months of follow-up. There is notable nucleus accumbens atrophy observed in MCI patients with DM. DM causes significant reductions in gray matter volume and sulcal depth. There are stronger correlations between cognitive decline and brain changes due to DM.