Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms.
Hamad M Al-MatarKamal M DawoodWael M TohamyPublished in: RSC advances (2018)
Several 2-arylcinnolin-6(2 H )-one derivatives were synthesized via tandem annulation of a large number of 3-oxo-2-arylhydrazonopropanals with acetoacetanilide under three different heating modes (conventional heating, ultrasound and microwave irradiation) using triethylamine in ethanol. The factors affecting the optimization of the annulation process were thoroughly studied. The annulated structures were established on the basis of 1 H and 13 C NMR and MALDI-TOF/MS spectral data as well as single crystal X-ray analysis.
Keyphrases
- high resolution
- solid state
- magnetic resonance imaging
- mass spectrometry
- dual energy
- radiofrequency ablation
- magnetic resonance
- optical coherence tomography
- electronic health record
- ultrasound guided
- contrast enhanced ultrasound
- structure activity relationship
- big data
- computed tomography
- artificial intelligence
- radiation induced
- deep learning
- contrast enhanced