Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury.

Katharine M IrvineAndrew D CloustonVictoria L GaddGregory C MillerWeng-Yew WongMichelle MelinoMuralidhara Rao MaradanaKelli MacDonaldRichard A LangMatthew J SweetAntje BlumenthalElizabeth E Powell

Published in: Fibrogenesis & tissue repair (2015)

In summary, these data suggest that macrophage-derived Wnt proteins possess anti-fibrogenic potential in chronic liver disease, which may be able to be manipulated for therapeutic benefit.

Keyphrases

liver injury
drug induced
liver fibrosis
induced apoptosis
stem cells
bone marrow
cell cycle arrest
cell proliferation
adipose tissue
acute myeloid leukemia
dendritic cells
human health
risk assessment
data analysis