Clopidogrel, a CYP2C8 inhibitor, causes a clinically relevant increase in the systemic exposure to the active metabolite of selexipag in healthy subjects.
Lene Nygaard AxelsenItalo PoggesiFreya RasschaertJuan Jose Perez RuixoShirin BrudererPublished in: British journal of clinical pharmacology (2020)
Results suggest that ACT-333679 exposure can be maintained within the therapeutic range by reducing selexipag dosing frequency to o.d. or dose to half, when selexipag is coadministered with clopidogrel.