CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis.

Ravi Shankar Keshari Robert Silasi-Mansat Narcis Ioan Popescu Girija Regmi Hala Chaaban John D Lambris Cristina Lupu Tom Eirik Mollnes Florea Lupu

Published in: Journal of thrombosis and haemostasis : JTH (2020)

Our results highlight the crosstalk between coagulation/fibrinolysis, inflammation, and complement systems and suggest a protective role of anti-CD14 treatment in E coli sepsis.

Keyphrases

escherichia coli
oxidative stress
acute kidney injury
septic shock
intensive care unit
nk cells
biofilm formation
free survival
replacement therapy
candida albicans