The Microminipig as an Animal Model for Influenza A Virus Infection.
Kiyoko Iwatsuki-HorimotoNoriko NakajimaMasatoshi ShibataKenta TakahashiYuko SatoMaki KisoSeiya YamayoshiMutsumi ItoSatoko EnyaMasayoshi OtakeAkihisa KangawaTiago Jose da Silva LopesHirotaka ItoHideki HasegawaYoshihiro KawaokaPublished in: Journal of virology (2017)
The microminipig is one of the smallest miniature pigs in the world and is used as an experimental animal model for life science research. In this study, we evaluated the microminipig as a novel animal model for influenza A virus infection. The distribution of influenza virus receptors in the respiratory tract of the microminipig was similar to that of the pig, and the sensitivity of microminipigs to influenza A viruses was the same as that of miniature pigs. Our findings suggest that microminipigs represent a novel animal model for influenza A virus infection.
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