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RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares.

Dana E OrangeVicky YaoKirsty SawickaJohn FakMayu O FrankSalina ParveenNathalie E BlachereCaryn HaleFan ZhangSoumya RaychaudhuriOlga G TroyanskayaRobert B Darnell
Published in: The New England journal of medicine (2020)
Longitudinal genomic analysis of rheumatoid arthritis flares revealed PRIME cells in the blood during the period before a flare and suggested a model in which these cells become activated by B cells in the weeks before a flare and subsequently migrate out of the blood into the synovium. (Funded by the National Institutes of Health and others.).
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