RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares.
Dana E OrangeVicky YaoKirsty SawickaJohn FakMayu O FrankSalina ParveenNathalie E BlachereCaryn HaleFan ZhangSoumya RaychaudhuriOlga G TroyanskayaRobert B DarnellPublished in: The New England journal of medicine (2020)
Longitudinal genomic analysis of rheumatoid arthritis flares revealed PRIME cells in the blood during the period before a flare and suggested a model in which these cells become activated by B cells in the weeks before a flare and subsequently migrate out of the blood into the synovium. (Funded by the National Institutes of Health and others.).
Keyphrases
- induced apoptosis
- rheumatoid arthritis
- cell cycle arrest
- healthcare
- public health
- endoplasmic reticulum stress
- mental health
- cell death
- signaling pathway
- disease activity
- oxidative stress
- gene expression
- dna methylation
- single cell
- quality improvement
- social media
- ankylosing spondylitis
- genome wide
- risk assessment
- systemic sclerosis
- idiopathic pulmonary fibrosis
- preterm birth
- human health
- bioinformatics analysis