GHS-R suppression in adipose tissues protects against obesity and insulin resistance by regulating adipose angiogenesis and fibrosis.

Jong Han LeeChuo FangXin LiChia-Shan Wu Ji Yeon NohXiangcang YeRobert S Chapkin Kai Sun Yuxiang Sun

Published in: International journal of obesity (2005) (2021)

These results show that GHS-R has cell-autonomous effects in adipocytes, and suppression of GHS-R in adipose tissues protects against diet-induced obesity and insulin resistance by modulating adipose angiogenesis and fibrosis. These findings suggest adipose GHS-R may constitute a novel therapeutic target for treatment of obesity and metabolic syndrome.

Keyphrases

insulin resistance
metabolic syndrome
adipose tissue
high fat diet induced
high fat diet
skeletal muscle
polycystic ovary syndrome
type diabetes
endothelial cells
vascular endothelial growth factor
uric acid
cardiovascular risk factors
glycemic control
stem cells
bone marrow
weight loss
liver fibrosis