Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis.
Chongguang YangBenjamin SobkowiakVijay NaiduAlexandru CodreanuNelly CiobanuKenneth S GunasekeraMelanie H ChitwoodSofia AlexandruStela BivolMarcus RussiJoshua HavumakiPatrick George Tobias CudahyHeather FosburghChristopher J AllenderHeather CentnerDavid M EngelthalerNicolas A MenziesJoshua L WarrenValeriu CruduCaroline ColijnTed CohenPublished in: PLoS medicine (2022)
The MDR-TB epidemic in Moldova is associated with the local transmission of multiple M. tuberculosis strains, including distinct clades of highly drug-resistant M. tuberculosis with varying geographic distributions and drug resistance profiles. This study demonstrates the role of comprehensive genomic surveillance for understanding the transmission of M. tuberculosis and highlights the urgency of interventions to interrupt transmission of highly drug-resistant M. tuberculosis.