Modulation of behavioral responses and CA1 neuronal death by nitric oxide in the neonatal rat's hypoxia model.

Zohreh GhotbeddinZahra BasirJavad JamshidianFarideh Delfi

Published in: Brain and behavior (2020)

Hypoxia damaged the neurons of hippocampal CA1 region and induced memory impairment. The NOS inhibitor, L-NAME, significantly attenuated the negative effects of hypoxia on behavior and observed changes in the hippocampus.

Keyphrases

nitric oxide
endothelial cells
cerebral ischemia
nitric oxide synthase
high glucose
spinal cord
oxidative stress
diabetic rats
working memory
protein kinase
hydrogen peroxide
spinal cord injury
cognitive impairment
drug induced